Search on: CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 4 
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Descriptor English:   Cyclic Nucleotide Phosphodiesterases, Type 4 
Descriptor Spanish:   Fosfodiesterasas de Nucleótidos Cíclicos Tipo 4 
Descriptor Portuguese:   Nucleotídeo Cíclico Fosfodiesterase do Tipo 4 
Tree Number:   D08.811.277.352.640.150.400
D12.644.360.008.400
D12.776.476.008.400
Definition English:   A cyclic nucleotide phosphodiesterase subfamily that is found predominantly in inflammatory cells and may play role in regulation of CELL-MEDIATED IMMUNITY. The enzyme family includes over twenty different variants that occur due to multiple alternative splicing of the mRNA of at least four different genes. 
History Note English:   2008(1981) 
Allowable Qualifiers English:  
administration & dosage adverse effects
antagonists & inhibitors analysis
biosynthesis blood
cerebrospinal fluid chemistry
classification chemical synthesis
contraindications drug effects
deficiency diagnostic use
economics genetics
history immunology
isolation & purification metabolism
pharmacology physiology
pharmacokinetics poisoning
radiation effects supply & distribution
secretion standards
toxicity therapeutic use
ultrastructure urine
Record Number:   52679 
Unique Identifier:   D054703 

Occurrence in VHL:
 

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